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Patrick Bright (Brian Van Holt)
LAPD officer Patrick Bright and his partner were called to a disturbance at a nightclub to find the place under seige from what appeared to be vampires. It was in the midst of fighting off the vampires that Patrick suddenly found himself chosen as a Champion by the Powers That Be, granted mystically enhanced strength and skills with which he was able to slay the creatures. Since then Patrick has found himself increasingly driven by his abilities to seek out and elminate supernatural evil. His new role as Champion has cost Patrick his job and his marriage, but he has found new allies in the fight against evil.

Jalen Shan Vinh (Byron Mann)
Taken as a baby from his village in Cambodia, Jalen Shan Vinh was raised by the ninja warriors of the Shadow Walker clan in their hidden temple. Trained to be one of their premiere assassins, Jalen instead rebelled against the clan while in Los Angeles on his first mission. He has since dedicated himself to using his skills against the forces of darkness. Jalen has since learned that he has a brother and that he is part heir of his family's fortune. During this time Jalen was also killed by the Shadow Clan who then resurrected his body with demonic powers. Jalen was able to regain control of his resurrected body and now must come to terms with his new abilities.

Lauren Sheppard (Tamara Braun)
Even as a child growing up in Beverly Hills, Lauren Sheppard exhibited telekinetic abilities. Fearful of how their "freak" daughter would affect their social standing, Lauren's parents went to great lengths to hide her abilities. After an incident in high school Lauren was sent to a psychiatrist recommended to her parents by Wolfram & Hart. The doctor was able to block Lauren's burgeoning psychic powers (until they could later be exploited) and Lauren returned to school. Years later the block was shattered when Lauren was chosen by the Powers That Be to be the new host for their Visions. Committed to an institution by her parents, Lauren was freed by Patrick and Jalen and is now trying to put together a new life while acting as the Powers' reluctant messenger to their Champions. Due in part to a failed attempt by Wolfram and Hart to sever her connection to the Powers, Lauren has now strengthened her clairvoyant abilities.

Dana Kincaid (Clea DuVall)
When she was four years old, Dana Kincaid's family was killed in front of her. The authorities never caught the killer, and little Dana knew why. It was because the killer was a monster, the kind that wasn't supposed exist in the real world. The trauma defined Dana's life and she grew up never forming close bonds with other people and pursuing a study of the supernatural that bordered on obsession. Her quest to identify the thing that killed her family has drawn her to Los Angeles, where she is working on a Masters in Occult Studies at UCLA. Despite her desire to be alone with her studies, Dana's obsession with the supernatural has caused her to join with the others in their battles against the forces of evil. During a battle with a werewolf Dana was cursed with lycanthropy, but has since gained a measure of control over her transformations.

Ethan Marsh (Eric Balfour)
A gifted medical student, Ethan Marsh's life was changed forever when he was nearly killed during an earthquake. Ethan's brush with death gave him a kind of "second sight" that lets him see the spirit world. Plagued by ghosts that no one else could see, Ethan turned to prescription drugs to get by. His increasingly erratic behavior led him to get kicked out of med school, forcing Ethan to find work at an inner city clinic. Circumstances drew him to the others and he has stayed with them, despite gaining a pair of unwanted roommates in the form of the homeless Jalen and Lauren. For Ethan the bad is balanced by being with people that he doesn't have to hide his ability from, and more recently with his efforts to get closer to the cold and distant Dana. More recently Ethan lost his job at the clinic, after which he was able to beat his drug addiction. He has also struck up something of a relationship with Alexandra Morelli, a lawyer working for the evil law firm of Wolfram and Hart.